RARA-AVIS: Re: RARA-AVIS Digest V2 #276

Lawrence R. (goldensam@sprintmail.com)
Wed, 29 Apr 1998 17:16:44 -0400 > >Dick--I refer to your comments to my comments below:
> >
> >> (I believe the American over-the-counter diet aid, dexatrim, refers to
> >> >the presciption stimulant dexetrine (?))
> >
> >Nope. Dexadrine is the brand name for dextroamphetamine, a cousin of
> >methamphetamine.Dexatrim, the over the counter stuff is just a brand name
> >wannabe. It is
> >actually similar to epinephrin (adrenaline) and is also used as a nasal
> >decongestant.
> >Its generic name is phenylpropanolamine and it is also peddled as Accutrim,
> >and Rhindecon
> >(when sold as a nasal decongestant.)
>
> By no means did I mean that the two drugs are the same, but rather the
> allusion is a marketing gimmick to make people think they're getting the
> real thing.

That is exactly the case; misunderstood your comment initially. Sorry.

> On decongestants: I took pseudoephedrine (sudafed) to be
> something of a stimulant--that ephedrine is also in the chinese herb
> mahuang (sp?), brewed for colds, which was incorporated into some of the
> smart drugs the kids were taking before they were banned in the last few
> years (under names such as "herbal ecstasy").

All the stuff mentioned are so called sympatheticomimetics, which is to say they all act like adrenaline, which of
course is what you feel like when you get a rush of adrenaline when you are threatened or frightened, etc.
So-called "fight and flight" response to danger: pupils open (so you can see better in bad light), mouth goes dry
(as part of slow-down of digestive system--you don't want to digest your pizza while being chased by a charging
rhino), heart beats faster, blood pressure goes up, etc etc..

> Also, since we're just
> getting our hard-boiled drug facts straight for versimilitude, could you
> comment on using stimulants to counter heroin and other narcotic
> overdoses

sure

> . Do people do this?

No. People take speed "uppers" to counteract effect of "downers", i.e. sedatives: barbiturates, Doriden, etc etc.
And vice-versa. This is what happened, for instance, to Jimi Hendrix, who was fed the stuff by managers, etc, so
that he could do 24 straight recording sessions. Same in reverse with Judy Garland when the studio stuffed her
with speed to keep her skinny, and then with barbiturates to let her rest.

> What do they do in hospitals?

Specific narcotic antagonists, the most widely used of which is Narcan (naloxone). This reverses the major effect
of narcotic overdose, which is that you stop breathing, which is not good for your health :-)Naloxone also is used
to reverse effects of severe alcohol and benzodiazepine overdose, and is also used in some neurological diseases,
such as spinal injury and strokes due to blood clots. Mechanism of action is not entirely clear in any of these
uses.

> Also,
> aren't benzodiazepines (sp?) used to counter ill effects of speed or
> other drugs?

It is used very commonly to avoid acute withdrawal symptoms in alcoholics and in speed and similar drugs and to
treat drug-induced seizures. It is also used in benzodiazepine addiction, by tapering slowly.

> While we're on the subject, what's in a Mickey Finn.

Chloral hydrate, which was once a popular sleeping medication, and is still around. Very cheap, but rarely
prescribed these days. It comes in a soft capsule, but was once available as a liquid (hence: knock out drops).
Had no taste, and could be put into a drink, giving you the famous cocktail "Mickey Finn".

> When
> Marlowe is getting drugged in Chandler books is it just morphine, or
> some other noxious substance.

Don't know--will check it out. Morphine though, would not be a drug of choice to "knock someone out."Before the
US Narcotic Laws came into effect (not sure exactly when) morphine was available easily. Some famous nostrums
like "Lydia Pinkham's Mixture" for "Female Problems", i.e. menses and what we now call PMS was loaded with
laudanum, which is deodorized tincture of opium --yummy-- and is still around but used only for diarrhea
occasionally. Paregoric is camphorated tincture of opium, same stuff but mixed with camphor to give it that vile
taste and smell so people will not use it to get stoned.

Besides Sherlock's addiction to cocaine, we have Sigmund Freud with the same problem. Three of the four founders
of John's Hopkins Medical School (including one of the greatest American surgeons), were addicted to morphine.
God knows what Nancy Reagan would have said had she known.

> Thanks for the expert witnessing.
>
> Doug

Hope this information is not overkill.--
Dick T

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