Michele Dougherty (leader of the Cassini mission to Saturn and its moons) was interviewed on The Life Scientific by Jim Al-Khalili, and there’s a nice exchange at the end:
Dougherty: It’s to do with confidence, and that you only build up over time. But what I’ve found, after I turned fifty—I don’t really care what anyone thinks: if I think it’s the right path, I do it anyway.
Al-Khalili: All of us over fifty feel like that.
Dougherty: It’s great, isn’t it? It’s great! I just wish I could have been like that in my twenties, but what the hell.